abstract：:Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is released in the tissue to...

journal_title：Pain

authors： Ebersberger A,Natura G,Eitner A,Halbhuber KJ,Rost R,Schaible HG

更新日期：2011-05-01 00:00:00

abstract：:Current knowledge on pain-related cerebral networks has relied so far on stimulus-induced brain responses, but not on the analysis of brain activity during spontaneous pain attacks. In this case report, correlation between intracerebral field potentials and online sensations during spontaneously painful epileptic seiz...

journal_title：Pain

authors： Isnard J,Magnin M,Jung J,Mauguière F,Garcia-Larrea L

更新日期：2011-04-01 00:00:00

abstract：:Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative stress have been regarded as important mechanisms in the pathogenesis of pain, the relationship between these 2 mechanisms has not been studied. To determine whether reactive oxygen species (ROS) involvement in pain mechanisms...

journal_title：Pain

authors： Yowtak J,Lee KY,Kim HY,Wang J,Kim HK,Chung K,Chung JM

更新日期：2011-04-01 00:00:00

abstract：:Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...

journal_title：Pain

authors： Rhudy JL,Martin SL,Terry EL,France CR,Bartley EJ,DelVentura JL,Kerr KL

更新日期：2011-04-01 00:00:00

abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...

journal_title：Pain

authors： Keefe FJ,Shelby RA,Somers TJ,Varia I,Blazing M,Waters SJ,McKee D,Silva S,She L,Blumenthal JA,O'Connor J,Knowles V,Johnson P,Bradley L

更新日期：2011-04-01 00:00:00

abstract：:The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...

journal_title：Pain

authors： Godínez-Chaparro B,Barragán-Iglesias P,Castañeda-Corral G,Rocha-González HI,Granados-Soto V

更新日期：2011-03-01 00:00:00

abstract：:We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...

journal_title：Pain

authors： de Andrade DC,Mhalla A,Adam F,Texeira MJ,Bouhassira D

更新日期：2011-02-01 00:00:00

abstract：:Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2...

journal_title：Pain

authors： Cogiamanian F,Vergari M,Schiaffi E,Marceglia S,Ardolino G,Barbieri S,Priori A

更新日期：2011-02-01 00:00:00

abstract：:Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching mindfulness meditation and mindful yoga exercises. MBSR aims to help participants develop nonjudgmental awareness of moment-to-moment experience. Fibromyalgia is a clinical syndrome with chronic pain, fatigue, and insomnia as major...

journal_title：Pain

authors： Schmidt S,Grossman P,Schwarzer B,Jena S,Naumann J,Walach H

更新日期：2011-02-01 00:00:00

abstract：:Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...

journal_title：Pain

authors： Kindermans HPJ,Huijnen IPJ,Goossens MEJB,Roelofs J,Verbunt JA,Vlaeyen JWS

更新日期：2011-02-01 00:00:00

abstract：:This study analyzed the relationship between the density of intraepidermal nerve fibers (IENF) and the characteristics of either nociceptive laser-evoked potentials (LEPs) or contact heat-evoked potentials (CHEPs) in patients with painful sensory polyneuropathy with the aim to determine which parameters of LEPs and CH...

journal_title：Pain

authors： Casanova-Molla J,Grau-Junyent JM,Morales M,Valls-Solé J

更新日期：2011-02-01 00:00:00

abstract：:Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance,...

journal_title：Pain

authors： Ray L,Lipton RB,Zimmerman ME,Katz MJ,Derby CA

更新日期：2011-01-01 00:00:00

abstract：:Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology....

journal_title：Pain

authors： Yan J,Edelmayer RM,Wei X,De Felice M,Porreca F,Dussor G

更新日期：2011-01-01 00:00:00

abstract：:To elucidate the mechanisms of antinociception mediated by the dopaminergic descending pathway in the spinal cord, we investigated the actions of dopamine (DA) on substantia gelatinosa (SG) neurons by in vivo whole-cell patch-clamp methods. In the voltage-clamp mode (V(H)=-70mV), the application of DA induced outward ...

journal_title：Pain

authors： Taniguchi W,Nakatsuka T,Miyazaki N,Yamada H,Takeda D,Fujita T,Kumamoto E,Yoshida M

更新日期：2011-01-01 00:00:00

abstract：:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...

journal_title：Pain

authors： Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJ

更新日期：2010-12-01 00:00:00

abstract：:The present prospective longitudinal study on chronic postoperative pain was conducted to assess the predictive power of attentional and emotional variables specifically assumed to augment pain, such as pain hypervigilance, pain-related anxiety, pain catastrophizing and attentional biases to pain. Their relevance was ...

journal_title：Pain

authors： Lautenbacher S,Huber C,Schöfer D,Kunz M,Parthum A,Weber PG,Roman C,Griessinger N,Sittl R

更新日期：2010-12-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...

journal_title：Pain

authors： Bosshard SC,Baltes C,Wyss MT,Mueggler T,Weber B,Rudin M

更新日期：2010-12-01 00:00:00

abstract：:Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...

journal_title：Pain

authors： Morasco BJ,Duckart JP,Carr TP,Deyo RA,Dobscha SK

更新日期：2010-12-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00

abstract：:A mounting body of literature recommends that treatment for fibromyalgia (FM) encompass medications, exercise and improvement of coping skills. However, there is a significant gap in determining an effective counterpart to pharmacotherapy that incorporates both exercise and coping. The aim of this randomized controlle...

journal_title：Pain

authors： Carson JW,Carson KM,Jones KD,Bennett RM,Wright CL,Mist SD

更新日期：2010-11-01 00:00:00

abstract：:The aim of this study was to investigate how exercise influenced endogenous pain modulation in healthy controls, shoulder myalgia patients and fibromyalgia (FM) patients. Twenty-one healthy subjects, 20 shoulder myalgia patients and 20 FM patients, all females, participated. They performed standardized static contract...

journal_title：Pain

authors： Lannersten L,Kosek E

更新日期：2010-10-01 00:00:00

abstract：UNLABELLED:The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) > or =6 weeks and an average pain score of VAS > or =50 mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservat...

journal_title：Pain

authors： Molsberger AF,Schneider T,Gotthardt H,Drabik A

更新日期：2010-10-01 00:00:00

abstract：:Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...

journal_title：Pain

authors： Wang Z,Ma W,Chabot JG,Quirion R

更新日期：2010-10-01 00:00:00

abstract：:This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...

journal_title：Pain

authors： Sharpe L,Perry NK,Rogers P,Dear BF,Nicholas MK,Refshauge K

更新日期：2010-09-01 00:00:00

abstract：:The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...

journal_title：Pain

authors： Patte-Mensah C,Meyer L,Schaeffer V,Mensah-Nyagan AG

更新日期：2010-09-01 00:00:00

abstract：:Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...

journal_title：Pain

authors： Horvath RJ,Romero-Sandoval AE,De Leo JA

更新日期：2010-09-01 00:00:00

abstract：:The goal of this study was to develop and validate a self-completed questionnaire, the Fibromyalgia Rapid Screening Tool (FiRST), for the detection of fibromyalgia syndrome in patients with diffuse chronic pain. Items requiring "yes/no" responses and relating to the most relevant clinical characteristics of fibromyalg...

journal_title：Pain

authors： Perrot S,Bouhassira D,Fermanian J,CEDR (Cercle d'Etude de la Douleur en Rhumatologie).

更新日期：2010-08-01 00:00:00

abstract：:Successful behavior requires the attentional selection and preferred processing of behaviorally relevant sensory information. Painful stimuli are of utmost behavioral relevance and can therefore involuntarily affect attentional resources and interfere with ongoing behavior. However, the neuronal mechanisms which subse...

journal_title：Pain

authors： Tiemann L,Schulz E,Gross J,Ploner M

更新日期：2010-08-01 00:00:00

abstract：:Behavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and opioid analgesia. However, there are also differences between the...

journal_title：Pain

authors： Petrovic P,Kalso E,Petersson KM,Andersson J,Fransson P,Ingvar M

更新日期：2010-07-01 00:00:00

abstract：:As part of a comprehensive study of the natural history of herpes zoster (HZ), 57 of 94 subjects in a cohort at elevated risk for post-herpetic neuralgia (PHN) consented to collection of 3-mm skin punch biopsies from affected, mirror-image, and distant control skin at baseline and followup visits. As cutaneous innerva...

journal_title：Pain

authors： Petersen KL,Rice FL,Farhadi M,Reda H,Rowbotham MC

更新日期：2010-07-01 00:00:00

abstract：:Non-invasive, movement-based models were used to investigate muscle pain. In rats, the masseter muscle was rapidly stretched or electrically stimulated during forced lengthening to produce eccentric muscle contractions (EC). Both EC and stretching disrupted scattered myofibers and produced intramuscular plasma extrava...

journal_title：Pain

authors： Dessem D,Ambalavanar R,Evancho M,Moutanni A,Yallampalli C,Bai G

更新日期：2010-05-01 00:00:00

abstract：:Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning,...

journal_title：Pain

authors： Geisser ME,Clauw DJ,Strand V,Gendreau MR,Palmer R,Williams DA

更新日期：2010-05-01 00:00:00

abstract：:Behavioral analgesic techniques such as distraction reduce pain in both clinical and experimental settings. Individuals differ in the magnitude of distraction-induced analgesia, and additional study is needed to identify the factors that influence the pain relieving effects of distraction. Catastrophizing, a set of ne...

journal_title：Pain

authors： Campbell CM,Witmer K,Simango M,Carteret A,Loggia ML,Campbell JN,Haythornthwaite JA,Edwards RR

更新日期：2010-05-01 00:00:00

abstract：:Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...

journal_title：Pain

authors： van Laarhoven AIM,Kraaimaat FW,Wilder-Smith OH,van de Kerkhof PCM,Evers AWM

更新日期：2010-05-01 00:00:00

abstract：:A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 pa...

journal_title：Pain

authors： Peng B,Pang X,Wu Y,Zhao C,Song X

更新日期：2010-04-01 00:00:00

abstract：:Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...

journal_title：Pain

authors： Sorkin LS,Otto M,Baldwin WM 3rd,Vail E,Gillies SD,Handgretinger R,Barfield RC,Yu HM,Yu AL

更新日期：2010-04-01 00:00:00

abstract：:The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (...

journal_title：Pain

authors： Blankenburg M,Boekens H,Hechler T,Maier C,Krumova E,Scherens A,Magerl W,Aksu F,Zernikow B

更新日期：2010-04-01 00:00:00

abstract：:Attenuation of neuropathic manifestations in experimental animals, by lidocaine injection in the rostral ventro-medial medulla (RVM), has been traditionally attributed to selective block of a descending pain facilitatory system. However, the presence of descending fibers carrying this effect and the selective action o...

journal_title：Pain

authors： Saadé NE,Al Amin H,Tchachaghian S,Jabbur SJ,Atweh SF

更新日期：2010-04-01 00:00:00

abstract：:This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold)...

journal_title：Pain

authors： da Costa DSM,Meotti FC,Andrade EL,Leal PC,Motta EM,Calixto JB

更新日期：2010-03-01 00:00:00

abstract：:Extraterritorial spread of sensory symptoms is frequent in carpal tunnel syndrome (CTS). Animal models suggest that this phenomenon may depend on central sensitization. We sought to obtain psychophysical evidence of sensitization in CTS with extraterritorial symptoms spread. We recruited 100 unilateral CTS patients. A...

journal_title：Pain

authors： Zanette G,Cacciatori C,Tamburin S

更新日期：2010-02-01 00:00:00